Boosting NAD+ Levels to Improve Fertility: The Latest Research Findings
In recent years, researchers have been studying the role of a molecule called nicotinamide adenine dinucleotide (NAD+) in fertility. NAD+ is involved in many cellular processes, including energy production and DNA repair. It has also been shown to play a key role in female reproductive health.
Studies have found that boosting NAD+ levels can improve fertility outcomes for women undergoing assisted reproductive technologies (ART), such as in vitro fertilization (IVF). In one study published in the journal Reproductive Sciences, researchers gave women with low ovarian reserve an oral supplement containing nicotinamide riboside, a compound that boosts NAD+ levels. They found that the treatment led to an increase in the number of eggs retrieved during IVF cycles and improved embryo quality.
Another study published in the Journal of Assisted Reproduction and Genetics looked at whether increasing NAD+ levels could improve egg quality. Researchers treated mouse oocytes with nicotinamide mononucleotide, another compound that increases NAD+. They found that this treatment led to better mitochondrial function and improved developmental potential of the eggs.
While these studies are promising, more research is needed to fully understand how boosting NAD+ levels affects fertility outcomes. However, there are already supplements available on the market containing compounds like nicotinamide riboside and nicotinamide mononucleotide for those looking to potentially improve their chances of conceiving through ART.
It’s important to note that while these supplements may be helpful for some individuals struggling with infertility due to low ovarian reserve or poor egg quality, they may not be effective for everyone. Consulting with a healthcare provider before starting any new supplement regimen is recommended.
Future Advances
As research into NAD+’s role in fertility continues, scientists are exploring other ways it could potentially be used as a treatment for infertility.
One area of interest is the use of NAD+ precursors, compounds that can be converted into NAD+ in the body. One such precursor is tryptophan, an amino acid found in many foods. A study published in Fertility and Sterility found that women with low ovarian reserve who consumed a diet high in tryptophan had improved fertility outcomes compared to those who did not.
Another potential avenue for research is the use of NAD+ as a treatment for male infertility. While much of the current research has focused on female fertility, studies have shown that NAD+ also plays a role in sperm function and quality. A study published in Andrology found that men with poor semen quality had lower levels of NAD+. The researchers suggested that boosting NAD+ levels could potentially improve sperm function and increase chances of conception.
In conclusion, while more research is needed to fully understand how boosting NAD+ levels affects fertility outcomes, early studies are promising. For individuals struggling with infertility due to low ovarian reserve or poor egg quality, supplements containing compounds like nicotinamide riboside and nicotinamide mononucleotide may be worth considering under medical supervision. As research continues on this topic, we may see new treatments emerge for both female and male infertility based on our understanding of the role of NAD+.
*Note: this site does not provide medical opinions or diagnosis and should not be relied upon instead of receiving medical attention from a licensed medical professional.
