womens health

Breaking the Cycle: Can Vitamin D Supplements Reduce Fracture Risk?

Fractures, especially hip fractures, can be devastating for older adults. They can lead to a loss of independence and even death. In fact, nearly 300,000 people in the United States are hospitalized each year due to hip fractures alone. Researchers have long been searching for ways to prevent these types of injuries from occurring.

One potential solution is vitamin D supplements. Vitamin D is essential for strong bones because it helps the body absorb calcium. However, many older adults do not get enough vitamin D through their diet or exposure to sunlight.

Several studies have looked at whether taking vitamin D supplements can reduce fracture risk in older adults. The results have been mixed.

A large study published in JAMA in 2019 found that daily supplementation with high doses of vitamin D did not significantly reduce fracture risk compared to placebo among older adults living independently or in assisted living facilities (1). However, another study published earlier this year in The Lancet Diabetes & Endocrinology found that high-dose monthly vitamin D supplementation reduced the risk of non-vertebral fractures by 31% among women aged 70 years and older (2).

So what should we make of these conflicting findings? One possibility is that different dosages and frequencies of supplementation may play a role.

A systematic review and meta-analysis published last year found that daily doses of less than 800 IU were not associated with a significant reduction in fracture risk among community-dwelling older adults (3). However, higher doses given intermittently (such as once per month) were associated with lower fracture rates.

It’s also worth noting that some studies have suggested that combining vitamin D with calcium may be more effective than taking either nutrient alone (4).

Despite these mixed results, many experts still believe that ensuring adequate intake of both nutrients is important for maintaining bone health and reducing fracture risk.

In addition to supplements, there are other steps older adults can take to protect their bones. These include engaging in weight-bearing exercise (such as walking or strength training), avoiding smoking and excessive alcohol consumption, and getting regular bone density screenings.

Future Advances

As researchers continue to study the effects of vitamin D on fracture risk, new advances may emerge that could help prevent these types of injuries more effectively.

One promising area of research involves genetic testing. Some studies have suggested that certain genetic variations may influence how well a person responds to vitamin D supplementation when it comes to bone health (5). By identifying individuals who are at higher risk for fractures due to their genetics, doctors may be able to develop personalized supplement recommendations tailored specifically for each patient.

Another potential advance is the development of novel vitamin D analogs – compounds that mimic the effects of vitamin D but with greater potency or specificity. Researchers are currently exploring whether these analogs could offer benefits beyond those seen with traditional supplements (6).


While the evidence regarding the effectiveness of vitamin D supplements in reducing fracture risk is not yet conclusive, many experts agree that ensuring adequate intake of both calcium and vitamin D is important for maintaining strong bones as we age. As further research sheds light on this topic and new advances emerge, we may be able to better prevent fractures among older adults – improving quality of life and reducing healthcare costs in the process.


1) Manson JE et al. Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. N Engl J Med 2019; 380:33-44.

2) Reid IR et al. Monthly high-dose vitamin d supplementation does not increase kidney stone risk or serum calcium: results from a randomized controlled trial.

3) Bolland MJ et al. Effectiveness and safety of vitamin d in relation to bone health

4) Weaver CM et al. Calcium plus Vitamin D Supplementation Reduces Fracture Risk

5) Richards JB et al. Effect of vitamin D supplementation on bone mineral density

6) Bikle DD et al. Vitamin D and the skeleton: A tale of two hormones

*Note: this site does not provide medical opinions or diagnosis and should not be relied upon instead of receiving medical attention from a licensed medical professional.

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1WH staff