womens health

The Role of NAD+ in Fertility: How This Molecule Affects Reproductive Health

Fertility is a crucial aspect of human life, and many couples struggle with infertility. Recent research has shown that the molecule Nicotinamide Adenine Dinucleotide (NAD+) plays a significant role in reproductive health.

What is NAD+?

NAD+ is an essential molecule found in all living cells. It plays a crucial role in energy production, DNA repair, and cell signaling. As we age, our levels of NAD+ decrease, which can lead to various health problems.

How does NAD+ affect fertility?

Research has shown that low levels of NAD+ can negatively impact fertility. In males, low levels of NAD+ have been linked to decreased sperm motility and abnormal morphology. In females, low levels of NAD+ have been associated with poor egg quality and reduced ovarian reserve.

One study conducted on mice showed that increasing their levels of NAD+ improved their fertility significantly. The researchers gave mice a supplement called nicotinamide mononucleotide (NMN), which increased their cellular levels of NAD+. After just four weeks, the NMN-treated mice had improved ovary function compared to the control group.

Another study conducted on humans found similar results. Women undergoing IVF treatment who took an NMN supplement had higher fertilization rates than those who didn’t take it.

Overall, these studies suggest that increasing cellular levels of NAD+ could improve reproductive health outcomes for both men and women.

Future Advances

Researchers are continuing to investigate how exactly NAD+ affects reproductive health and how it could be used as a therapeutic target for infertility treatment.

One area being explored is whether boosting cellular levels of other molecules related to metabolism can also improve fertility outcomes. For example, another study conducted on mice showed that increasing their cellular levelssulfur amino acid methionine improved their fertility.

Additionally, researchers are investigating whether NAD+ supplementation could improve outcomes for those undergoing IVF treatment. One study published in the Journal of Assisted Reproduction and Genetics found that women undergoing IVF who took an NMN supplement had higher implantation rates than those who didn’t take it.


Infertility is a challenging issue faced by many couples worldwide. While there are various treatments available, recent research has shown that increasing cellular levels of NAD+ could be a promising avenue for improving reproductive health outcomes. As we continue to learn more about how this molecule affects fertility, we may see new therapies emerge that can help more people start families.

*Note: this site does not provide medical opinions or diagnosis and should not be relied upon instead of receiving medical attention from a licensed medical professional.

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1WH staff