womens health
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Understanding the Link Between NAD+ and Female Fertility Issues

In recent years, scientists have been studying the link between a molecule called nicotinamide adenine dinucleotide (NAD+) and female fertility issues. NAD+ is essential for many cellular processes, including energy production and DNA repair. Studies suggest that low levels of NAD+ may be linked to infertility in women.

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What is NAD+?

NAD+ is a coenzyme found in all living cells. It plays an important role in many biological processes, including metabolism, DNA repair, and aging. As we age, our bodies produce less NAD+, which can lead to various health problems.

The Role of NAD+ in Female Fertility

Studies suggest that low levels of NAD+ may be linked to infertility in women. In one study published in the journal Cell Reports, researchers found that mice with lower levels of NAD+ had fewer eggs available for fertilization than mice with higher levels of the molecule.

Another study published in Science Advances found that increasing levels of another molecule called NMN (nicotinamide mononucleotide), which boosts cellular levels of NAD+, improved fertility outcomes in older female mice.

While these studies were conducted on animals rather than humans, they provide valuable insights into how changes in cellular metabolism can affect reproductive function.

How Can We Increase Levels of NAD+

There are several ways to increase levels of NAD+. One way is through diet – foods such as milk, fish, poultry and nuts contain high amounts of niacin or vitamin B3 which helps boost its level naturally. Another way is through supplements like Nicotinamide Riboside(NR) or Nicotinamide Mononucleotide(NMN).

Future Advances

Researchers are continuing to explore the link between low levels of NDA +and female fertility issues. Some studies also suggest that boosting cellular levels could help improve other aspects of reproductive health, such as reducing the risk of miscarriage and improving embryo quality.

In a study published in Nature Communications, researchers found that increasing NAD+ levels in female mice led to improved mitochondrial function in their eggs, which could help improve fertility outcomes. Mitochondria are structures within cells that produce energy; they play an important role in many biological processes, including reproduction.

Another study published in the journal Aging Cell found that boosting cellular levels of NAD+ helped reduce DNA damage and inflammation associated with aging. This suggests that increasing NAD+ levels could have broader benefits beyond just reproductive health.


While more research is needed to fully understand the link between NDA +and female fertility issues, studies suggest that low levels of this molecule may be a contributing factor. Boosting cellular levels through diet or supplements like NR or NMN may help improve fertility outcomes for some women. As scientists continue to explore this topic, we may see new treatments emerge that can help couples struggling with infertility achieve their dream of starting a family.


1) Irie et al., “Low Cellular NAD Compromises Lipid Metabolism and Fertility through Energy Depletion,” Cell Reports (2018).

2) Mills et al., “Nicotinamide Mononucleotide Boosts Mitochondrial Quality and Function To Enhance Germline Stem Cell Maintenance,” Science Advances (2020).

3) Ryu et al., “NAD+ Repletion Improves Mitochondrial and Stem Cell Function and Enhances Life Span in Mice,” Science (2016).

*Note: this site does not provide medical opinions or diagnosis and should not be relied upon instead of receiving medical attention from a licensed medical professional.

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